BROMELAIN POWDER (ANANAS COMOSUS)(STEM)(STD. TO 2400 GDU/G)

Bromelain is a complex mixture of proteolytic enzymes derived from the stem and fruit of the pineapple plant (Ananas comosus). This specific ingredient, standardized to 2400 GDU/g (Gelatin Digesting Units per gram), indicates a high level of enzymatic activity, crucial for its therapeutic efficacy. Historically, pineapple has been utilized in traditional medicine across South and Central America for its digestive and anti-inflammatory properties. The stem variety of bromelain is particularly valued for its higher concentration of enzymes compared to fruit bromelain, making it a potent ingredient for various applications. Its extraction process typically involves crushing the pineapple stem, followed by filtration, ultrafiltration, and lyophilization to yield a stable, high-purity powder. The standardization to GDU/g ensures consistent proteolytic activity, a critical quality parameter for supplement manufacturers aiming for predictable product performance and consumer benefits. This enzyme blend is known for its broad substrate specificity, capable of hydrolyzing various proteins into smaller peptides and amino acids, a fundamental aspect of its biological actions.

The primary health benefits of bromelain stem from its multifaceted enzymatic activity, particularly its potent proteolytic and fibrinolytic effects. Research suggests its efficacy in modulating inflammatory responses, with studies indicating its ability to inhibit pro-inflammatory mediators such as prostaglandins and thromboxane. For instance, a review in *Integrative Medicine, A Clinician's Journal* highlighted bromelain's capacity to reduce swelling and pain, especially post-surgery or injury, by influencing cytokine production and reducing plasma fibrinogen levels. Beyond inflammation, bromelain supports digestive health by aiding in the breakdown of proteins, which can alleviate indigestion and improve nutrient absorption. Its fibrinolytic action, demonstrated in various *in vitro* and *in vivo* studies, contributes to its potential role in cardiovascular health by helping to prevent excessive blood clotting. The active compounds are primarily cysteine proteases, alongside various other non-proteolytic components like phosphatases, glucosidases, peroxidases, cellulases, and protease inhibitors, which collectively contribute to its broad spectrum of biological activities.

Bromelain powder standardized to 2400 GDU/g is highly versatile for supplement formulations, commonly incorporated into digestive enzyme blends, joint support formulas, and post-exercise recovery products. It is available in various dosage forms, including capsules, tablets, and powders, often combined with other anti-inflammatory agents like turmeric or boswellia, or digestive aids such as papain. Quality considerations are paramount; manufacturers must ensure the raw material is non-GMO, free from contaminants, and processed under GMP standards to preserve enzyme activity. Scientific evidence continues to support bromelain's therapeutic potential. A meta-analysis published in *Phytomedicine* examining its use in osteoarthritis patients found significant reductions in pain and improvements in physical function compared to placebo. Another study in *Clinical Immunology* explored its immunomodulatory effects, suggesting its role in influencing immune cell function. These robust findings underscore bromelain's position as a scientifically-backed ingredient for a range of health applications, emphasizing the importance of consistent enzymatic activity for optimal results.