Calcium Butyrate {Microencapsulated, granular 40 mesh}

Calcium Butyrate, specifically in its microencapsulated, granular 40 mesh form, represents a sophisticated advancement in delivering butyric acid, a vital short-chain fatty acid (SCFA). Butyrate is naturally produced in the colon by the fermentation of dietary fiber by commensal gut bacteria, serving as the primary energy source for colonocytes, the cells lining the colon. The innovative microencapsulation technology is paramount to this ingredient's efficacy, as it protects the highly volatile butyric acid from degradation by stomach acid and early absorption in the upper gastrointestinal tract. This protective barrier ensures targeted and sustained release of butyrate directly into the colon, where it exerts its most profound benefits. The granular 40 mesh specification further enhances its applicability in manufacturing, providing excellent flowability, reduced hygroscopicity, and a masked odor profile, which are crucial for product stability and consumer palatability in various supplement formulations.

Butyrate's health benefits are largely centered on its multifaceted role in maintaining gut homeostasis and modulating systemic physiological processes. As an SCFA, it plays a critical role in strengthening the intestinal barrier function by promoting tight junction integrity, thereby reducing gut permeability. Furthermore, butyrate is recognized for its potent anti-inflammatory properties, acting by inhibiting histone deacetylase (HDAC) enzymes, which influences gene expression related to inflammation and cellular proliferation. Research published in journals like *Gut* highlights butyrate's capacity to reduce pro-inflammatory cytokine production, such as TNF-alpha and IL-6, within the gut mucosa. Beyond the gastrointestinal tract, emerging scientific evidence suggests butyrate's involvement in metabolic regulation, including glucose and lipid metabolism, and its potential to influence immune system responses, underscoring its broad therapeutic potential as a key bioactive compound.

This microencapsulated Calcium Butyrate is an ideal ingredient for a wide range of dietary supplements aimed at supporting digestive health, gut barrier integrity, and overall wellness. Its controlled-release properties make it particularly suitable for formulations targeting conditions requiring localized colonic support. Quality considerations for this ingredient emphasize the importance of the microencapsulation method, ensuring both the stability and bioavailability of butyrate upon reaching the lower gut. Scientific research continues to validate the benefits of butyrate supplementation; for instance, a study in the *Journal of Gastroenterology and Hepatology* demonstrated that oral butyrate supplementation can improve symptoms in patients with irritable bowel syndrome (IBS) by modulating gut motility and reducing visceral hypersensitivity. The combination with calcium also provides synergistic benefits for bone health, making it a comprehensive ingredient for advanced health formulations.