Cascara Sagrada Bark Extract (std. to 10% Hydroxyanthracene)

Cascara Sagrada, derived from the dried bark of the Rhamnus purshiana tree native to the Pacific Northwest, is a historically recognized botanical ingredient primarily valued for its digestive health properties. The name "Cascara Sagrada" translates to "sacred bark," a testament to its long-standing traditional use among indigenous peoples for supporting bowel regularity. This botanical extract is characterized by its unique phytochemical profile, predominantly featuring a group of compounds known as anthraquinone glycosides. Our Cascara Sagrada Bark Extract is meticulously standardized to contain 10% Hydroxyanthracene derivatives, ensuring a consistent and potent concentration of its primary bioactive constituents. This standardization is critical for delivering reliable efficacy in finished supplement formulations, providing a natural option for promoting healthy digestive function. The bark undergoes a specific drying and aging process before extraction to mitigate harshness, a practice rooted in traditional knowledge and validated by modern understanding of its chemical transformation.

The primary health benefit of Cascara Sagrada is its well-established role as a stimulant laxative, facilitating bowel movements and alleviating occasional constipation. Its mechanism of action is attributed to the anthraquinone glycosides, particularly the cascarosides (A, B, C, D). Upon ingestion, these inactive glycosides travel to the colon where they are metabolized by gut bacteria into active aglycones, such as aloe-emodin and rhein. These active compounds then exert their effects by stimulating colonic peristalsis, increasing the rhythmic contractions of the large intestine, and by inhibiting water and electrolyte absorption from the bowel lumen. This dual action results in softer stool consistency and increased stool volume, promoting easier and more frequent bowel evacuation. Scientific studies, including those reviewed by the European Medicines Agency (EMA), have consistently supported the efficacy of anthraquinone-containing laxatives for short-term relief of occasional constipation, highlighting the importance of standardized extracts for predictable results.

Cascara Sagrada Bark Extract, standardized to 10% Hydroxyanthracene, is widely utilized in dietary supplement formulations aimed at supporting digestive regularity. It is commonly incorporated into capsules, tablets, and powdered blends designed for occasional constipation relief or as part of broader digestive support complexes. Due to its potent activity, it is often combined with gentler fibers or prebiotics to provide comprehensive gut health benefits. Quality assurance is paramount for this ingredient, requiring rigorous testing for botanical identity, purity, and the precise quantification of hydroxyanthracene content to meet label claims. Reputable suppliers ensure the absence of contaminants like heavy metals and pesticides, adhering to strict Good Manufacturing Practices (GMP). Research continues to explore the optimal dosing and long-term safety profile, emphasizing its use for short-term support as recommended by various health authorities. Its centuries of traditional use, coupled with modern scientific validation, solidify its position as a valuable botanical for digestive wellness.