COLEUS FORSKOHLII EXTRACT (ROOT)(STD. TO 20% FORSKOLIN)

Coleus forskohlii (Plectranthus barbatus) is a perennial herb belonging to the mint family (Lamiaceae), native to subtropical regions of India, Nepal, and Thailand. For centuries, its tuberous roots have been a staple in traditional Ayurvedic medicine, revered for their diverse therapeutic properties, particularly in addressing respiratory, cardiovascular, and digestive ailments. The extract derived from these roots is highly valued in modern nutraceuticals, primarily due to its active diterpenoid compound, forskolin. This specific extract is standardized to contain 20% forskolin, ensuring a consistent and potent concentration of the primary bioactive constituent. This standardization is crucial for product efficacy and reproducibility in research and commercial applications, reflecting a commitment to quality and scientific rigor in supplement formulation. The root extract typically presents as a fine, brownish powder with a characteristic aroma, indicating its natural botanical origin.

The primary mechanism of action for Coleus forskohlii extract centers around its active compound, forskolin. Forskolin is a potent activator of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP). Increased intracellular cAMP levels are a key secondary messenger involved in numerous physiological processes, including the regulation of metabolism, hormone secretion, and cardiovascular function. This elevation in cAMP has been linked to several health benefits, such as supporting fat metabolism by activating hormone-sensitive lipase, which facilitates the breakdown of stored triglycerides. Furthermore, forskolin's influence on cAMP can contribute to bronchodilation, potentially aiding respiratory function, and may also support healthy blood pressure by promoting smooth muscle relaxation in blood vessels. Beyond forskolin, Coleus forskohlii roots contain other phytochemicals, including other diterpenoids and triterpenes, though forskolin remains the most extensively studied and primary active component responsible for its well-documented effects.

Coleus forskohlii extract, standardized to 20% forskolin, is a versatile ingredient widely applied in dietary supplements targeting weight management, cardiovascular health, and respiratory support. It is commonly found in capsule, tablet, and powder formulations, often combined with synergistic ingredients like L-carnitine or green tea extract to enhance metabolic benefits. Quality considerations for this extract include ensuring proper botanical identification, verifying the standardization of forskolin content via validated analytical methods like HPLC, and screening for contaminants such as heavy metals and pesticides. Clinical studies have explored forskolin's role in body composition, with some research indicating a potential for modest reductions in body fat when combined with lifestyle interventions, as evidenced in a study published in the Journal of the International Society of Sports Nutrition. Other research suggests its utility in maintaining healthy intraocular pressure and supporting respiratory comfort, building upon its traditional uses and providing a scientific basis for its inclusion in contemporary health formulations.