FEVERFEW EXTRACT 4:1 (LEAVES AND FLOWERS)

Feverfew (Tanacetum parthenium), a perennial herbaceous plant from the Asteraceae family, has a rich history of traditional use, particularly for its recognized properties in alleviating discomfort. This 4:1 extract, derived from the leaves and flowers, concentrates the plant's beneficial compounds, meaning four parts of the raw plant material are used to produce one part of the extract, enhancing its potency. Native to the Balkan Peninsula, feverfew is now cultivated globally for its medicinal value. The plant is characterized by its small, daisy-like flowers and aromatic leaves, which have been employed in European folk medicine for centuries, primarily for headaches and inflammatory conditions. The extraction process carefully preserves the delicate balance of its phytochemical profile, ensuring a high-quality ingredient suitable for sophisticated supplement formulations.

The primary health benefits of feverfew are largely attributed to its sesquiterpene lactones, particularly parthenolide, which is considered the main active compound. Research suggests parthenolide may modulate inflammatory pathways by inhibiting the release of serotonin from platelets and interfering with prostaglandin synthesis. Studies have shown its ability to inhibit NF-κB activation, a key regulator of immune and inflammatory responses, which contributes to its traditional use in managing discomfort. Furthermore, other compounds like flavonoids (e.g., apigenin, luteolin) and volatile oils present in feverfew contribute to its overall synergistic effects, offering additional antioxidant and anti-inflammatory properties. This multi-compound approach underpins its efficacy in supporting various physiological functions.

Feverfew extract is a valuable ingredient for formulations targeting discomfort relief, inflammatory support, and general well-being. It is commonly incorporated into capsules, tablets, and sometimes liquid formulations. When selecting feverfew extract, standardized extracts, often guaranteeing a minimum parthenolide content, are preferred to ensure consistent potency and efficacy, aligning with rigorous quality control standards. Clinical studies, such as a meta-analysis published in The Cochrane Database of Systematic Reviews, have reviewed its efficacy in specific applications, lending scientific credence to its long-standing traditional use. Manufacturers often combine feverfew with other botanicals like ginger or white willow bark to create synergistic blends for enhanced effects, offering comprehensive support for various health concerns.