HOODIA GORDONII EXTRACT 12:1 (STEM)

Hoodia Gordonii Extract 12:1 (STEM) is derived from the succulent plant *Hoodia gordonii*, a species native to the arid regions of Southern Africa, particularly the Kalahari Desert. Traditionally, the indigenous San people have consumed the plant's stem for centuries to suppress hunger and thirst during long hunting expeditions, leveraging its natural properties to endure strenuous periods without sustenance. Our 12:1 extract signifies a highly concentrated form, meaning 12 parts of raw Hoodia gordonii stem are used to produce one part of the extract, enhancing the potency of its beneficial compounds. This meticulous concentration process ensures a higher yield of the active constituents responsible for its reputed effects, providing a standardized and effective ingredient for supplement formulations. The plant's unique adaptation to harsh desert conditions contributes to its distinct phytochemical profile, which is carefully preserved during the extraction process to deliver a high-quality raw material.

The primary bioactive compound identified in Hoodia gordonii is a steroidal glycoside known as P57, which is believed to be responsible for its appetite-suppressing properties. Research suggests that P57 may act on the central nervous system, specifically the hypothalamus, by mimicking the effect of glucose on nerve cells. This mechanism is thought to signal satiety to the brain, thereby reducing appetite and caloric intake. A study published in the *Journal of Ethnopharmacology* highlighted the traditional use and preliminary pharmacological investigations into Hoodia's anorexigenic potential, supporting the hypothesis that its unique compounds interact with neural pathways regulating hunger. While human clinical trials have yielded mixed results, some studies, such as one reported in the *American Journal of Clinical Nutrition*, have indicated a trend towards reduced caloric intake and body weight in participants consuming Hoodia extracts, although more robust, large-scale research is still warranted to fully elucidate its efficacy and optimal dosage.

Hoodia Gordonii Extract 12:1 (STEM) is a sought-after ingredient in dietary supplements primarily targeted at weight management and appetite control. Its application is typically found in capsule or tablet formulations, often as a standalone ingredient or combined with synergistic compounds like green tea extract or conjugated linoleic acid (CLA) to enhance metabolic support. Quality assurance is paramount for Hoodia gordonii due to historical concerns regarding adulteration and misidentification in the market. Reputable suppliers ensure authenticity through rigorous botanical identification, including DNA barcoding and High-Performance Liquid Chromatography (HPLC) to verify the presence and concentration of P57. This commitment to purity and standardization ensures that formulators receive a product that aligns with scientific evidence and regulatory expectations. Ongoing research continues to explore the precise pharmacokinetics and long-term safety profile of P57 and other Hoodia compounds, further solidifying its role in evidence-based supplement development for satiety support.