L-CITRULLINE DL-MALATE EXTRACT 2:1

L-Citrulline DL-Malate 2:1 is a well-regarded compound in sports nutrition and general wellness, combining the non-essential amino acid L-Citrulline with malic acid, a dicarboxylic acid involved in the Krebs cycle. This specific 2:1 ratio indicates that for every two parts of L-Citrulline, there is one part of DL-Malate, a racemic mixture of L-malic acid and D-malic acid. L-Citrulline is naturally found in foods like watermelon, while malate is present in various fruits. This synergistic combination is engineered to enhance bioavailability and efficacy, offering distinct advantages over L-Citrulline alone. Its powdered form allows for versatile integration into various supplement formulations. The L-Citrulline component serves as a precursor to L-arginine, which is critical for nitric oxide (NO) production, a key vasodilator. Malate, on the other hand, plays a crucial role in cellular energy production, supporting the ATP cycle.

The primary health benefits of L-Citrulline DL-Malate 2:1 stem from its dual action on nitric oxide synthesis and energy metabolism. L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic metabolism and leading to a more sustained increase in plasma L-arginine levels than L-arginine supplementation itself. Elevated L-arginine then boosts nitric oxide production, which relaxes blood vessels, improving blood flow and nutrient delivery to working muscles. This mechanism has been extensively studied for its potential to enhance exercise performance and reduce muscle fatigue. The malate component contributes to cellular energy production by facilitating the Krebs cycle, which is essential for aerobic respiration. Research, such as a study published in the British Journal of Sports Medicine, has shown that citrulline malate can significantly improve athletic performance and reduce post-exercise muscle soreness, likely due to enhanced ATP production and ammonia detoxification. Furthermore, L-Citrulline also plays a role in the urea cycle, aiding in the removal of ammonia, a byproduct of intense exercise, which can contribute to fatigue.

L-Citrulline DL-Malate 2:1 is widely incorporated into pre-workout formulas, intra-workout supplements, and post-exercise recovery blends due to its robust support for performance and recovery. Its application extends beyond sports nutrition to cardiovascular health, where improved vasodilation can be beneficial. When sourcing this ingredient, manufacturers prioritize purity, ensuring minimal contaminants and consistent potency. High-performance liquid chromatography (HPLC) is often employed to verify the 2:1 ratio and the absence of impurities. Clinical trials have consistently demonstrated the ergogenic effects of L-Citrulline DL-Malate. For instance, a meta-analysis in the Journal of Strength and Conditioning Research concluded that citrulline supplementation significantly improved resistance exercise performance, while another study in the European Journal of Sport Science highlighted its benefits for endurance exercise. These findings underscore its evidence-backed efficacy, making it a valuable component for formulations targeting enhanced physical output, reduced fatigue, and improved vascular function.