LICORICE EXTRACT 20:1 (GLYCYRRHIZA GLABRA) (ROOT)

Glycyrrhiza glabra, commonly known as licorice, is a perennial herb native to southern Europe and Asia. The extract is derived from its root, which has been utilized for centuries in traditional medicine systems, including Traditional Chinese Medicine (TCM) and Ayurvedic practices, for its diverse therapeutic properties. This 20:1 concentrated extract signifies that 20 parts of raw licorice root were used to produce 1 part of the finished extract, ensuring a potent concentration of its beneficial compounds. The root's characteristic sweet taste is primarily due to glycyrrhizin, a triterpenoid saponin, which is significantly sweeter than sucrose. Beyond its flavor profile, licorice root is recognized for its complex phytochemical composition, making it a valuable ingredient in modern nutraceutical formulations. The extraction process typically involves water or hydroalcoholic solvents to isolate these active constituents efficiently.

Licorice extract's health benefits are largely attributed to its rich array of bioactive compounds, particularly triterpenoid saponins like glycyrrhizin (also known as glycyrrhizic acid) and flavonoids such as liquiritin and isoliquiritigenin. Research indicates that glycyrrhizin exhibits significant anti-inflammatory and antiviral properties. For instance, studies have shown its ability to modulate immune responses by inhibiting the metabolism of corticosteroids, thereby prolonging their half-life and enhancing their anti-inflammatory effects, as observed in various in vitro and in vivo models. Furthermore, flavonoids in licorice contribute to its antioxidant capacity, helping to neutralize free radicals and reduce oxidative stress, which is a key factor in numerous chronic diseases. The adaptogenic qualities of licorice also support the body's resilience to stress, with some evidence suggesting a role in adrenal support.

Due to its versatile properties, Licorice Extract 20:1 finds broad application in supplement formulations targeting digestive health, respiratory support, and immune modulation. For digestive health, it is often incorporated into products aimed at soothing the gastrointestinal tract and supporting mucosal integrity, with deglycyrrhizinated licorice (DGL) being a common variant used to minimize potential side effects of glycyrrhizin. Research published in journals like Phytotherapy Research has highlighted its role in gastric protection. In respiratory applications, its expectorant and demulcent properties are valued for easing coughs and sore throats. Quality considerations for licorice extract include standardization to specific active compounds, such as glycyrrhizin content, to ensure consistent potency and efficacy. Traceability of the raw material and rigorous testing for contaminants like heavy metals and pesticides are crucial for consumer safety and product integrity.