VITAMIN K (AS VITAMIN K2)(MENAQUINONE-7)(MK-7 1.0%)

Vitamin K is an essential fat-soluble vitamin recognized for its crucial role in coagulation. However, its often-overlooked isoform, Vitamin K2, particularly Menaquinone-7 (MK-7), offers distinct and profound benefits beyond blood clotting. Unlike Vitamin K1 (phylloquinone), predominantly found in leafy green vegetables and involved in hepatic coagulation, MK-7 is primarily synthesized by bacteria during fermentation and is abundant in traditional fermented foods like natto. This specific menaquinone homolog stands out due to its longer half-life and superior bioavailability, allowing for sustained systemic presence and more efficient utilization by extra-hepatic tissues. Its unique molecular structure enables it to travel freely in the bloodstream, reaching tissues such as bone and arteries where it plays a critical regulatory role. This makes MK-7 a highly sought-after ingredient for targeted nutritional support.

The profound health benefits of Vitamin K2 (MK-7) are primarily mediated through its activation of specific vitamin K-dependent proteins (VKDPs). Two crucial VKDPs are osteocalcin and matrix Gla protein (MGP). Osteocalcin, produced by osteoblasts, requires carboxylation by K2 to effectively bind calcium ions, thereby facilitating the integration of calcium into the bone matrix and promoting optimal bone mineralization. Concurrently, MGP, found abundantly in vascular smooth muscle cells, acts as a potent inhibitor of arterial calcification. Activated MGP sequesters calcium from soft tissues, preventing its deposition in arterial walls and maintaining vascular flexibility. Research, including studies published in the *Journal of Atherosclerosis and Thrombosis*, has illuminated MK-7's role in arterial health, demonstrating its capacity to improve arterial elasticity and reduce the progression of arterial stiffening, thus supporting cardiovascular well-being.

Given its pivotal physiological functions, Vitamin K2 (MK-7) is a highly valued ingredient in various supplement formulations. It is commonly incorporated into bone health supplements, often synergistically combined with Vitamin D3 and calcium, to optimize calcium utilization and bone mineral density. Furthermore, its cardiovascular protective properties make it ideal for heart health formulations, either as a standalone ingredient or alongside omega-3 fatty acids and magnesium. For manufacturers, sourcing high-quality MK-7, such as the specified MK-7 1.0% powder, is paramount to ensure efficacy and stability. Clinical trials, including a notable study in *Osteoporosis International*, have provided robust evidence that daily supplementation with MK-7 significantly improves bone mineral content and reduces bone loss, particularly in postmenopausal women. These findings underscore its therapeutic potential and support its inclusion in evidence-based nutritional products designed for long-term health maintenance.