Nattokinase

Nattokinase is a potent proteolytic enzyme derived from natto, a traditional Japanese food made from fermented soybeans. This unique enzyme is produced by the bacterium Bacillus subtilis natto during the fermentation process, which transforms soybeans into their characteristic sticky, pungent form. Historically consumed for centuries in Japan, natto’s health benefits have long been recognized, with modern science pinpointing Nattokinase as a key active component. The enzyme is a serine protease, meaning it utilizes a serine residue in its active site to break down proteins. Its discovery in 1987 by Dr. Hiroyuki Sumi, who observed its remarkable fibrinolytic activity, propelled Nattokinase into the spotlight as a significant natural ingredient for cardiovascular support. Its distinct molecular structure allows it to effectively hydrolyze fibrin, the protein responsible for blood clot formation, making it a subject of extensive research for its potential circulatory benefits.

The primary mechanism of action for Nattokinase revolves around its powerful fibrinolytic properties, directly degrading fibrin and enhancing the body's natural clot-dissolving processes. Research indicates that Nattokinase not only directly cleaves fibrin but also increases the production of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA), thereby boosting the body's endogenous fibrinolytic capacity. Beyond its direct fibrin-degrading effects, Nattokinase has been shown to support healthy blood pressure. A randomized, double-blind, placebo-controlled study published in Hypertension Research (Kim et al., 2008) demonstrated that Nattokinase supplementation significantly reduced both systolic and diastolic blood pressure in individuals with pre-hypertension or stage 1 hypertension. Furthermore, studies suggest it may help reduce blood viscosity and inhibit platelet aggregation, contributing to improved overall blood flow and reduced risk factors associated with cardiovascular strain. These multifaceted actions underscore its potential as a comprehensive circulatory health ingredient.

In supplement formulations, Nattokinase is typically standardized by its fibrinolytic units (FU), a measure of its enzymatic activity, ensuring consistent potency and efficacy across batches. High-quality Nattokinase ingredients are often produced through controlled fermentation processes, followed by purification to remove unwanted components while preserving enzyme activity. This ingredient is commonly found in capsules or tablets designed for oral administration, often alongside other synergistic cardiovascular compounds such as Coenzyme Q10, omega-3 fatty acids, or garlic extract, to provide broader circulatory support. Scientific evidence continues to accumulate, with a meta-analysis by Ren et al. (2017) in Medicine concluding that Nattokinase supplementation significantly decreased both systolic and diastolic blood pressure. Its safety profile, coupled with its demonstrated efficacy in human trials, makes it a valuable addition to dietary supplements aimed at supporting cardiovascular wellness, maintaining healthy blood flow, and promoting overall circulatory function.