POMEGRANATE EXTRACT 4:1 (FRUIT)

Pomegranate Extract 4:1 is derived from the fruit of Punica granatum, a species revered for centuries in traditional medicinal systems like Ayurveda and Unani. This specific extract ratio signifies that four parts of the raw pomegranate fruit material are concentrated into one part of the final extract, ensuring a potent and concentrated source of its beneficial compounds. Native to regions spanning from Iran to northern India, the pomegranate fruit is globally recognized for its vibrant color, distinctive flavor, and exceptional nutritional profile. The extraction process carefully isolates the fruit's key bioactive constituents, making it a highly sought-after ingredient in the dietary supplement industry for its consistent quality and efficacy. Its rich history and scientific validation underscore its value as a foundational component in health-focused formulations.

The profound health benefits of Pomegranate Extract are primarily attributed to its high concentration of polyphenolic compounds, most notably ellagitannins like punicalagins, as well as anthocyanins and other flavonoids. These compounds are potent antioxidants, effectively neutralizing free radicals and mitigating oxidative stress, a primary driver of cellular aging and chronic disease. Research published in the *Journal of Agricultural and Food Chemistry* has highlighted the superior antioxidant capacity of punicalagins compared to many other known antioxidants. Furthermore, pomegranate polyphenols exhibit significant anti-inflammatory properties by modulating key inflammatory pathways, such as the NF-κB pathway. This dual action of antioxidant and anti-inflammatory support makes it particularly beneficial for cardiovascular health, aiding in the maintenance of healthy blood pressure and cholesterol levels, and supporting endothelial function.

In supplement formulations, Pomegranate Extract 4:1 is highly versatile, commonly found in capsules, powders, and functional beverages. For optimal efficacy and consistency, extracts are often standardized to their punicalagin content, ensuring a reliable concentration of the primary active compound. Quality considerations for this ingredient include meticulous sourcing of the fruit, employing gentle extraction methods (such as water or ethanol extraction to preserve sensitive compounds), and rigorous testing for purity, including heavy metals and pesticide residues. Clinical trials, such as those published in *Atherosclerosis*, have demonstrated the potential of pomegranate to reduce carotid intima-media thickness, a marker of arterial plaque buildup, further solidifying its role in cardiovascular support. Its concentrated form provides a more potent and convenient delivery of these scientifically-backed benefits.