DE-111™ (BACILLUS SUBTILIS)

DE-111™ is a highly researched, spore-forming probiotic strain of Bacillus subtilis, renowned for its stability and efficacy in supporting gut health. Unlike many common probiotic strains that are sensitive to harsh gastric conditions, DE-111™ forms a protective endospore, allowing it to survive passage through the acidic environment of the stomach and reach the intestinal tract intact. This resilience ensures its viability and ability to colonize the gut effectively, a crucial factor for probiotic function. Originating from naturally occurring strains found in fermented foods and soil, Bacillus subtilis has a long history of safe use and has been extensively studied for its beneficial effects on the human microbiome. Its unique spore-forming capability makes it an ideal candidate for various supplement formulations, offering superior shelf-stability and resistance to processing conditions compared to non-spore-forming probiotics. The strain's robust nature contributes significantly to its ability to modulate the gut microbiota and support overall digestive wellness.

The primary health benefits of DE-111™ stem from its ability to enhance the gut microbial balance and support digestive function. Research indicates that DE-111™ helps to crowd out undesirable bacteria while promoting the growth of beneficial flora, thereby contributing to a healthier gut ecosystem. Studies have shown its capacity to support the normal breakdown of complex carbohydrates and fats, aiding in nutrient absorption. Furthermore, DE-111™ has been demonstrated to support immune function, with clinical trials illustrating its positive impact on the body's natural defenses, particularly in the gut-associated lymphoid tissue (GALT). Its mechanisms involve the production of various enzymes, such as amylase, protease, and lipase, which assist in digestion, and the secretion of antimicrobial compounds that inhibit pathogenic bacteria. This comprehensive action contributes to reducing occasional digestive discomfort, supporting regularity, and enhancing overall gastrointestinal well-being, as evidenced by studies published in journals like *Beneficial Microbes*.

DE-111™ is widely applicable in a diverse range of supplement formulations due to its exceptional stability. It can be incorporated into capsules, tablets, powders, and even functional foods and beverages without significant loss of viability, a distinct advantage over many other probiotic strains. Quality considerations for DE-111™ emphasize rigorous testing for strain identity, potency (colony-forming units, CFUs), and purity, ensuring the absence of contaminants. Scientific research, including randomized, placebo-controlled clinical trials, has consistently supported its efficacy. For instance, a study published in *Foods* journal highlighted DE-111™'s role in improving body composition and athletic performance in conjunction with protein supplementation. Another study in *Journal of Probiotics & Health* demonstrated its ability to support healthy cholesterol levels already within the normal range. These robust findings underscore DE-111™ as a scientifically-backed ingredient for digestive health, immune support, and broader wellness applications, making it a valuable asset for formulators seeking reliable and effective probiotic solutions.