JAPANESE KNOTWEED EXTRACT (20% RESVERATROL)(POLYGONUM CUSPIDATUM)(ROOT)

Japanese Knotweed (Polygonum cuspidatum), also known as Fallopia japonica or Reynoutria japonica, is a perennial herbaceous plant native to East Asia, particularly Japan, China, and Korea. Historically, its rhizome (root) has been a staple in traditional Asian medicine, notably in Traditional Chinese Medicine (TCM) where it is called Hu Zhang. It is highly valued for its rich phytochemical profile, particularly as a significant natural source of trans-resveratrol. This extract, standardized to 20% resveratrol, ensures a potent and consistent concentration of this key bioactive compound. The root of Polygonum cuspidatum is carefully processed to isolate and concentrate its beneficial constituents, making it a preferred raw material for dietary supplements targeting cellular health and longevity. Its robust nature and widespread distribution underscore its historical and ongoing importance in ethnobotanical practices. This specific extract leverages modern extraction techniques to deliver a high-purity ingredient.

The primary health benefits of Japanese Knotweed extract are largely attributed to its high concentration of trans-resveratrol, a stilbenoid polyphenol. Resveratrol is renowned for its potent antioxidant properties, which help neutralize free radicals and reduce oxidative stress, a key contributor to cellular aging and various chronic conditions. Research indicates resveratrol's ability to activate sirtuins, a class of proteins involved in cellular regulation, metabolism, and DNA repair, thereby influencing longevity pathways. Studies, such as those published in "Nature" and "Cell Metabolism," have explored its role in mitochondrial function and energy production. Furthermore, resveratrol exhibits significant anti-inflammatory actions by modulating various inflammatory pathways, including the inhibition of cyclooxygenase-2 (COX-2) and nuclear factor-kappa B (NF-κB). These multifaceted mechanisms contribute to its potential in supporting cardiovascular health, healthy aging, and overall cellular resilience.

Japanese Knotweed extract, particularly when standardized to 20% trans-resveratrol, is a versatile ingredient for various supplement formulations. It is commonly incorporated into anti-aging, cardiovascular support, and antioxidant complexes, often in powder or capsule forms. Quality considerations are paramount, including ensuring the extract is free from heavy metals, pesticides, and other contaminants, adhering to stringent cGMP standards. Scientific literature, including numerous in vitro, in vivo, and human clinical trials, continues to elucidate resveratrol's therapeutic potential. For instance, a meta-analysis in "Nutrients" highlighted its efficacy in improving certain markers of cardiovascular health. Its application extends to formulations aimed at supporting metabolic health, cognitive function, and even skin vitality. The standardization to 20% resveratrol guarantees a consistent and efficacious dose, allowing formulators to precisely control the active compound content in their final products, ensuring both potency and reproducibility.