JAPANESE KNOTWEED EXTRACT (50% RESVERATROL)(POLYGONUM CUSPIDATUM)(ROOT)

Japanese Knotweed Extract, derived from the root of Polygonum cuspidatum, is a highly valued botanical ingredient in the supplement industry, primarily recognized for its rich concentration of trans-resveratrol. This perennial herbaceous plant, native to East Asia, has a long history of traditional use in various Asian herbal medicine systems, particularly Traditional Chinese Medicine (TCM), where it is known as "Hu Zhang." The extract typically undergoes a meticulous purification process to standardize its active compound content, ensuring consistent potency and efficacy. Our Japanese Knotweed Extract is specifically standardized to contain 50% trans-resveratrol, the biologically active isoform of resveratrol, which is crucial for its beneficial effects. This careful sourcing and standardization underscore its premium quality and suitability for high-performance supplement formulations, minimizing contaminants while maximizing the yield of this potent polyphenol.

The primary health benefits of Japanese Knotweed Extract are largely attributed to its high trans-resveratrol content, a potent polyphenol renowned for its robust antioxidant and anti-inflammatory properties. Scientific research indicates that resveratrol can activate sirtuin proteins, particularly SIRT1, which play a critical role in cellular health, DNA repair, and longevity pathways. This mechanism contributes to its anti-aging potential and support for cellular regeneration. Furthermore, resveratrol has been shown to modulate inflammatory pathways, such as the NF-κB pathway, helping to mitigate oxidative stress and systemic inflammation, as demonstrated in various in vitro and in vivo studies. Its cardiovascular benefits are also well-documented, with studies suggesting improvements in endothelial function and lipid profiles, contributing to overall heart health. Beyond resveratrol, Polygonum cuspidatum also contains other beneficial compounds like emodin, polydatin, and anthraquinones, which synergistically contribute to its broad spectrum of therapeutic actions.

This 50% Resveratrol Japanese Knotweed Extract is a versatile ingredient, ideal for various supplement formulations targeting anti-aging, cardiovascular support, and antioxidant defense. It is commonly incorporated into capsules, tablets, and powdered blends, often combined with other synergistic compounds like CoQ10, quercetin, or vitamin C to enhance its bioavailability and efficacy. Quality control is paramount, involving rigorous testing for purity, potency, and absence of heavy metals or pesticides, ensuring compliance with strict industry standards. Extensive research supports resveratrol's health claims; for instance, a meta-analysis published in Nutrients (2019) highlighted its significant impact on inflammatory biomarkers. Clinical trials, such as those investigating its effects on metabolic syndrome, continue to elucidate its potential, reinforcing its status as an evidence-backed ingredient. Its traditional use over centuries provides an historical context, now validated by modern scientific inquiry, making it a reliable choice for premium health products.