JAPANESE KNOTWEED EXTRACT (98% RESVERATROL)(POLYGONUM CUSPIDATUM)(ROOT)

Japanese Knotweed Extract, derived from the root of *Polygonum cuspidatum*, is a highly valued botanical ingredient renowned for its rich content of trans-resveratrol. Historically known as Hu Zhang in traditional East Asian medicine, where it has been utilized for centuries for its various health-supporting properties, this plant serves as a robust natural source for this potent polyphenol. Our extract is meticulously standardized to 98% trans-resveratrol, ensuring unparalleled purity, potency, and consistency for formulators. This high level of standardization guarantees that each batch delivers a precise concentration of the active compound, making it an ideal choice for premium supplement applications. The extraction process typically involves careful solvent-based methods designed to isolate and concentrate trans-resveratrol, yielding a fine, characteristic powder that is easily incorporated into diverse formulations. This botanical ingredient offers a reliable and scientifically validated alternative to grape-derived resveratrol, providing a concentrated and consistent source of this extensively researched compound.

Trans-resveratrol is the primary bioactive compound responsible for the extract's extensive health benefits, acting through multiple intricate mechanisms. It is widely recognized for its powerful antioxidant capabilities, effectively neutralizing free radicals and mitigating oxidative stress, a key contributor to cellular damage and aging. Furthermore, resveratrol has been shown to modulate critical cellular signaling pathways, including activating sirtuins (specifically SIRT1), which are enzymes linked to cellular longevity and DNA repair, and influencing AMPK, an enzyme vital for energy metabolism. Research, such as studies reviewed by Smoliga et al. (2011), highlights its significant role in cardiovascular health by promoting vasodilation and reducing oxidative stress on endothelial cells. Its anti-inflammatory properties are attributed to its ability to inhibit pro-inflammatory mediators, contributing to overall systemic balance. Beyond trans-resveratrol, Japanese Knotweed also contains minor amounts of other beneficial compounds like polydatin (a resveratrol glycoside), emodin, and various flavonoids, which may contribute synergistically to its comprehensive bioactivity.

This high-purity Japanese Knotweed extract finds broad application in the formulation of advanced dietary supplements targeting anti-aging, cardiovascular support, cognitive function, and metabolic health. It is commonly incorporated into capsules, tablets, powdered blends, and functional food products. Ensuring the quality of this ingredient is paramount, involving rigorous testing for heavy metals, pesticides, and microbial contaminants to meet stringent industry standards. The standardization to 98% trans-resveratrol is a critical quality marker, guaranteeing consistent efficacy and enabling precise dosing in finished products. Extensive preclinical and human clinical trials continue to elucidate resveratrol's multifaceted benefits, with meta-analyses, such as that by Liu et al. (2014), demonstrating its potential to improve markers of endothelial function. Further scientific investigations, including work reviewed by Timmers et al. (2011), explore its impact on mitochondrial biogenesis and energy metabolism, mirroring effects observed with caloric restriction. For optimal bioavailability and stability in formulations, micronization or lipid-based delivery systems are often considered, making this ingredient a scientifically robust choice for formulators seeking to deliver evidence-backed health solutions.