Setria® L- Glutathione (Reduced)

Setria® L-Glutathione is a patented, clinically studied form of glutathione. It's a tripeptide composed of three amino acids: L-cysteine, L-glutamic acid, and glycine. Glutathione is endogenously produced in the body and plays a crucial role in various physiological processes, particularly detoxification and antioxidant defense. The "reduced" form, also known as GSH, is the active form capable of donating an electron, which is essential for neutralizing free radicals. Setria® is known for its high purity and stability, ensuring bioavailability. Its unique manufacturing process by Kyowa Hakko Bio ensures a consistent, high-quality ingredient, distinguishing it from generic glutathione products. This specific formulation is designed to resist gastric degradation, a common challenge with oral glutathione supplementation, thereby enhancing its delivery and efficacy within the body's systems. This makes it a preferred choice for formulators seeking reliable glutathione support.

The primary mechanism of action for L-Glutathione revolves around its powerful antioxidant capabilities. As the body's master antioxidant, it directly neutralizes reactive oxygen species (ROS) and free radicals, protecting cells from oxidative damage. Furthermore, glutathione is a critical cofactor for several antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which are integral to the cellular defense system. Beyond its direct antioxidant role, glutathione is pivotal in detoxification processes, particularly in the liver. It facilitates the conjugation of toxins, heavy metals, and xenobiotics, rendering them water-soluble and easier for the body to excrete. Research has shown its involvement in immune function, supporting the proliferation and differentiation of lymphocytes and influencing cytokine production, thereby modulating immune responses. Studies have indicated that maintaining optimal glutathione levels is correlated with enhanced cellular protection and overall physiological resilience. Its role extends to supporting mitochondrial function and energy production, highlighting its foundational importance in cellular health.

Setria® L-Glutathione is widely incorporated into various dietary supplement formulations, including capsules, powders, and functional beverages, due to its enhanced stability and bioavailability. Clinical studies have demonstrated the efficacy of Setria® in increasing glutathione levels in the blood and supporting immune function. For instance, a randomized, double-blind, placebo-controlled study published in the Journal of Nutritional Science and Vitaminology showed that daily oral supplementation with Setria® L-Glutathione significantly increased whole blood glutathione levels and improved NK cell activity in healthy adults. Another study highlighted its role in reducing oxidative stress markers and improving skin health parameters. When considering quality, the manufacturing process of Setria® ensures exceptional purity and absence of impurities, which is critical for an ingredient intended for systemic support. Formulators often combine Setria® with synergistic nutrients like Vitamin C or N-acetylcysteine (NAC) to further optimize its antioxidant and detoxification pathways, leveraging scientific understanding to maximize consumer benefits.