APIGENIN 98% (CITRUS AURANTIUM)

Apigenin 98% derived from Citrus aurantium, commonly known as bitter orange, represents a highly purified natural flavone celebrated for its diverse biological activities. As a prominent member of the flavonoid family, apigenin is also naturally abundant in various plant sources such as chamomile, parsley, and celery, where it plays critical roles in plant defense mechanisms, including protection against UV radiation and pathogen attack. Our Apigenin 98% is meticulously processed to ensure a minimum purity of 98%, yielding a fine, yellow crystalline powder. This high level of purity is crucial for consistent efficacy and allows for precise dosing in supplement formulations, making it an ideal ingredient for developers seeking a potent and reliable botanical extract. The rigorous standardization ensures that the inherent phytochemical integrity and beneficial properties of apigenin are maximized for human consumption.

The health benefits attributed to apigenin are extensive and are primarily mediated through its potent antioxidant and anti-inflammatory properties. Mechanistically, apigenin exerts its anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines, such as TNF-α and IL-6, and by modulating key enzymes like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), as demonstrated in numerous in vitro and in vivo studies. Furthermore, its antioxidant capacity involves direct scavenging of free radicals and the upregulation of endogenous antioxidant enzymes, including superoxide dismutase and catalase, thereby protecting cellular components from oxidative damage. Beyond these fundamental roles, apigenin is recognized for its neuroprotective potential, attributed to its ability to cross the blood-brain barrier and modulate GABA-A receptor activity, which contributes to its well-documented anxiolytic and mild sedative effects, promoting relaxation and supporting restful sleep.

Apigenin 98% is a versatile ingredient widely applicable in various supplement formulations targeting sleep support, stress reduction, cognitive health, and general wellness. It is typically incorporated into encapsulated products, powdered blends, or functional food and beverage matrices. The quality of Apigenin 98% is paramount, necessitating stringent quality control measures including third-party testing for heavy metals, pesticides, and microbial contaminants to ensure safety and purity. Scientific research continues to uncover the broad therapeutic potential of apigenin. For instance, a meta-analysis of studies published in Phytotherapy Research highlighted the anxiolytic effects of apigenin-rich extracts, validating its traditional use in calming preparations. Preclinical studies also explore its anti-carcinogenic properties through mechanisms like inducing apoptosis and inhibiting angiogenesis, though human clinical trials are ongoing. Optimizing bioavailability, possibly through advanced delivery systems, remains a key focus in maximizing its therapeutic impact, ensuring that this powerful flavonoid delivers its full spectrum of benefits effectively.