DIOSMIN 90% (CITRUS AURANTIUM)(FRUIT)

Diosmin 90% is a highly purified flavonoid glycoside derived primarily from the fruit of Citrus aurantium, commonly known as bitter orange. This ingredient is meticulously processed to achieve a minimum 90% diosmin content, ensuring a potent and consistent active profile for supplement formulations. As a member of the flavonoid family, diosmin is recognized for its significant biological activity, particularly in supporting vascular integrity and function. Historically, citrus bioflavonoids have been utilized in traditional medicine for their various health-promoting properties. Modern scientific interest in diosmin stems from its well-documented role in promoting circulatory health, making it a cornerstone ingredient in formulations targeting venous insufficiency and related conditions. Its extraction and standardization ensure a high-quality raw material suitable for diverse dietary supplement applications, reflecting a commitment to both traditional efficacy and modern scientific precision.

The primary health benefits of Diosmin 90% are rooted in its venotonic and vasoprotective actions. Research indicates that diosmin works by prolonging the vasoconstrictor effect of norepinephrine on the venous wall, thereby increasing venous tone and reducing venous distensibility. This mechanism helps to decrease venous capacitance, stasis, and hyperpermeability. Furthermore, diosmin has been shown to reduce capillary permeability and improve lymphatic drainage, which are crucial for mitigating edema and swelling. Studies, such as those published in "Angiology," highlight its efficacy in managing symptoms of chronic venous insufficiency (CVI), including leg pain, heaviness, and nocturnal cramps. Its anti-inflammatory and antioxidant properties also contribute to its vascular protective effects, supporting overall endothelial health by reducing oxidative stress and inflammatory responses within the circulatory system.

In supplement formulations, Diosmin 90% is frequently utilized in products aimed at supporting venous health, managing hemorrhoids, and alleviating symptoms associated with lymphedema. For optimal absorption and bioavailability, diosmin is often micronized, a process that reduces particle size and significantly enhances its assimilation in the gastrointestinal tract, as demonstrated in pharmacokinetic studies. Clinical trials have consistently supported the therapeutic benefits of diosmin, particularly when combined with hesperidin (a common co-constituent in citrus extracts), in improving microcirculation and reducing CVI symptoms. For formulators, sourcing Diosmin 90% involves rigorous quality control to ensure purity, potency, and compliance with regulatory standards. Its robust scientific backing and established safety profile make it an invaluable ingredient for developing evidence-based products targeting a wide range of circulatory health concerns, offering a natural yet scientifically validated approach to vascular wellness.