Japanese Knotweed Extract 10:1 (Polygonum cuspidatum)(root)

Japanese Knotweed Extract 10:1 (Polygonum cuspidatum), derived from the robust root of a perennial herbaceous plant native to East Asia, is a highly valued ingredient in the nutraceutical industry. Known traditionally as Hu Zhang in Traditional Chinese Medicine (TCM), its historical use spans centuries for promoting overall well-being. This specific 10:1 extract signifies a concentrated form, where ten parts of the raw botanical material are used to produce one part of the extract, ensuring a potent and efficacious product. The root is meticulously harvested and processed to isolate its rich array of bioactive compounds, making it a cornerstone for formulations targeting various health aspects. Its deep cultural roots and established traditional efficacy lay the foundation for its modern scientific exploration, highlighting its significance beyond mere botanical classification. The careful extraction process preserves the integrity of its complex phytochemical profile, crucial for delivering its full spectrum of benefits.

At the core of Japanese Knotweed's health benefits lies its impressive concentration of polyphenolic compounds, most notably trans-resveratrol. This potent stilbenoid is widely recognized for its powerful antioxidant properties, effectively neutralizing free radicals and mitigating oxidative stress, a primary contributor to cellular aging and damage. Beyond its antioxidant capacity, resveratrol, along with other active constituents like emodin and physcion, exhibits significant anti-inflammatory effects by modulating various inflammatory pathways and cytokine production, as evidenced in numerous in vitro and in vivo studies. Research published in journals like *Circulation* and *Molecular Nutrition & Food Research* highlights resveratrol's role in supporting cardiovascular health by promoting endothelial function, improving vasodilation, and contributing to healthy lipid metabolism. These synergistic compounds work together to support cellular integrity and systemic balance, offering comprehensive support for vital physiological processes and contributing to its broad therapeutic potential.

Japanese Knotweed Extract 10:1 finds versatile application in a range of dietary supplements, including capsules, powders for functional beverages, and specialized liquid formulations. It is frequently incorporated into products designed for cardiovascular support, anti-aging complexes, and immune-modulating formulas due to its well-documented benefits. For formulators, ensuring the extract's quality is paramount; this includes rigorous testing for purity, potency, and standardization to a specific percentage of resveratrol to guarantee consistent efficacy. Clinical trials, such as those detailed in the *American Journal of Clinical Nutrition*, have explored resveratrol's impact on human health, demonstrating its bioavailability and positive effects on markers of inflammation and oxidative stress. The 10:1 concentration ensures a robust profile, making it an ideal choice for high-quality, evidence-based supplement development. Combining this extract with other synergistic ingredients, such as CoQ10 or Vitamin C, can further enhance its protective and supportive effects, creating comprehensive health solutions.