REHMANNIAE RADIX 10:1 EXTRACT (ROOT)

Rehmanniae Radix, commonly known as Di Huang, is a revered herb in Traditional Chinese Medicine (TCM), derived from the root of Rehmannia glutinosa. This 10:1 extract concentrates the plant's beneficial compounds, signifying that ten parts of the raw root are used to produce one part of the extract, enhancing potency. Historically, it has been categorized into raw (Sheng Di Huang) and prepared (Shu Di Huang) forms, each with distinct therapeutic profiles. Sheng Di Huang is known for its "clearing heat" and "cooling blood" properties, while Shu Di Huang, after processing, is primarily used for "tonifying blood" and "nourishing yin." Our extract typically aligns with the prepared form's properties due to the extraction process, focusing on its restorative and tonic attributes. Its rich dark color and characteristic aroma are indicators of its concentrated nature and phytochemical density, making it a valuable ingredient for modern supplement formulations aimed at holistic health support. The plant thrives in temperate regions, with its root being the primary medicinal part harvested for its extensive traditional applications.

The profound health benefits of Rehmanniae Radix are largely attributed to its complex profile of bioactive compounds, particularly iridoid glycosides such as catalpol and various rehmanniosides (A, B, C, D). Catalpol, a prominent iridoid, has been extensively studied for its neuroprotective, anti-inflammatory, and antioxidant activities, as demonstrated in various *in vitro* and *in vivo* models. Research suggests that these compounds may exert their effects by modulating inflammatory pathways, such as inhibiting NF-κB activation, and by scavenging reactive oxygen species, thereby reducing oxidative stress. Furthermore, Rehmanniae Radix contains phenethyl alcohol glycosides like acteoside, which also contribute to its antioxidant capacity. Traditional applications highlight its role in supporting kidney and liver function, and modern research corroborates these uses, with studies indicating potential nephroprotective and hepatoprotective effects, possibly by enhancing cellular defense mechanisms and reducing tissue damage. Its adaptogenic qualities are also recognized, helping the body manage stress and maintain homeostasis.

Rehmanniae Radix 10:1 extract is highly versatile for incorporation into various supplement formulations, including capsules, tablets, and functional beverage mixes, often synergizing with other traditional herbs like Cornus officinalis and Dioscorea opposita. For optimal efficacy and safety, sourcing this ingredient requires stringent quality control, ensuring it is free from heavy metals, pesticides, and microbial contaminants, and that the concentration of active markers like catalpol is standardized. Scientific investigations have explored its potential in managing conditions like type 2 diabetes, where it has shown promise in improving glucose metabolism and insulin sensitivity in animal studies, aligning with its traditional use for "wasting and thirsting disease." A meta-analysis published in the *Journal of Ethnopharmacology* highlighted its beneficial effects on kidney health, suggesting its utility in supporting renal function. Further clinical trials are ongoing to fully elucidate its therapeutic potential and establish standardized dosages for various health indications, reinforcing its position as a scientifically relevant botanical.