Relora® (proprietary blend of Magnolia officinalis bark extract and Phellodendron amurense bark extract)

Relora® is a distinctive, patented blend derived from the bark of two traditional medicinal plants: *Magnolia officinalis* and *Phellodendron amurense*. Both botanicals have a long history of use in Traditional Chinese Medicine (TCM) for their calming and stress-reducing properties. *Magnolia officinalis* bark is rich in lignans, particularly honokiol and magnolol, while *Phellodendron amurense* bark contains isoquinoline alkaloids, including berberine and phellodendrine. This proprietary combination is meticulously extracted and standardized to ensure a consistent profile of these key bioactive compounds, providing a synergistic effect aimed at supporting the body’s natural response to stress. Unlike many calming agents, Relora® is designed to promote relaxation without inducing drowsiness, making it suitable for daytime use in managing everyday stressors and promoting a balanced mood. Its unique composition targets specific physiological pathways involved in stress perception and response, establishing it as a premium ingredient in the adaptogenic category.

The primary health benefits of Relora® stem from its ability to help normalize levels of stress hormones, particularly cortisol. Clinical research indicates that the honokiol and magnolol from *Magnolia officinalis* may modulate the activity of the hypothalamic-pituitary-adrenal (HPA) axis, thereby reducing the physiological responses to stress. These lignans are also recognized for their potential to interact with GABA-A receptors, promoting a calming effect on the central nervous system. Concurrently, the alkaloids from *Phellodendron amurense*, such as berberine, contribute to its adaptogenic profile by supporting overall metabolic health and potentially exerting anti-inflammatory actions, which can be beneficial in a stress-compromised state. A randomized, placebo-controlled study demonstrated that Relora® significantly reduced perceived stress levels and improved mood states in moderately stressed adults, highlighting its efficacy in supporting emotional well-being without sedation.

Relora® is a versatile ingredient for various supplement formulations, including capsules, powders, and functional food applications, offering a natural solution for stress management. Its robust scientific backing ensures its suitability for products aimed at promoting relaxation, supporting mood, and even assisting with stress-related weight management, particularly for individuals prone to stress-induced eating. Quality considerations for Relora® include stringent standardization of active compounds (honokiol, magnolol, berberine), ensuring purity, and verifying non-GMO status. Further research has confirmed its role in reducing salivary cortisol levels and improving sleep quality metrics in individuals experiencing stress, reinforcing its broad utility. The synergistic action of its botanical constituents provides a comprehensive approach to stress adaptation, making Relora® a highly sought-after component in evidence-based health products committed to efficacy and consumer well-being.