Affron®: Saffron (Crocus Sativus L.) stigmas extract [Std. to 3.5% Lepticrosalides® by HPLC]

Affron® is a premium, standardized saffron extract derived from the stigmas of Crocus sativus L., a perennial flowering plant historically cultivated in the Mediterranean and Middle East. It's distinguished by its rigorous standardization to 3.5% Lepticrosalides® via High-Performance Liquid Chromatography (HPLC), a proprietary complex of bioactive compounds unique to saffron. This precise standardization ensures consistent potency and efficacy, setting it apart from generic saffron extracts. Saffron has been revered for centuries in traditional Persian medicine and Ayurvedic practices for its diverse health-promoting properties, often referred to as "red gold" due to its high value and potent benefits. Affron® utilizes a patented extraction process from sustainably grown Spanish saffron, guaranteeing purity and traceability from farm to finished product. The extract typically presents as a fine, reddish-orange powder, easily incorporated into various supplement matrices.

The primary health benefits of Affron® are largely attributed to its unique profile of Lepticrosalides®, which include crocin, picrocrocin, and safranal. These compounds exert multifaceted pharmacological actions, most notably in mood regulation and cognitive function. Research suggests that saffron's mechanisms of action involve modulating neurotransmitter systems, particularly serotonin, dopamine, and norepinephrine, which play crucial roles in mood, stress response, and cognitive processes. For instance, studies indicate saffron's ability to inhibit the reuptake of monoamines and modulate GABAergic and glutamatergic systems, contributing to its anxiolytic and antidepressant-like effects. A randomized, double-blind, placebo-controlled study published in the Journal of Affective Disorders demonstrated significant improvements in mood scores among participants supplemented with Affron® over several weeks. Beyond mood, the carotenoids like crocin and crocetin in saffron exhibit powerful antioxidant and anti-inflammatory properties, protecting neuronal cells from oxidative stress and supporting overall brain health.

Affron® is widely utilized in dietary supplements targeting mood support, stress relief, and cognitive enhancement. Its high standardization and consistent efficacy make it an ideal choice for premium formulations. It can be formulated into capsules, tablets, powders, and functional foods. Its compatibility with other adaptogens like Ashwagandha or nootropics like Bacopa monnieri offers synergistic potential in comprehensive wellness products. Quality control is paramount with saffron extracts due to adulteration risks; Affron® addresses this through its stringent standardization and authenticated source, providing a reliable and pure ingredient. Multiple clinical trials support Affron®'s efficacy. A study in Complementary Therapies in Medicine highlighted its positive impact on sleep quality and mood in healthy adults. Another investigation focused on adolescents experiencing occasional nervous tension and low mood, showing favorable outcomes with Affron® supplementation. This robust scientific backing, coupled with its traditional use, positions Affron® as a leading evidence-based ingredient for mental well-being and cognitive health, ensuring consumer confidence and product integrity.