GRANULAR QUERCETIN DIHYDRATE (SOPHORA JAPONICA)(FLOWER BUD)

Quercetin dihydrate, a prominent flavonoid, is naturally derived from the flower buds of Sophora japonica, also known as the Japanese pagoda tree. This granular form offers enhanced handling and solubility characteristics compared to its anhydrous counterpart, making it highly suitable for diverse supplement formulations. As a polyphenolic compound, quercetin is widely distributed in various plant-based foods, but Sophora japonica stands out as a particularly rich and concentrated botanical source. The dihydrate form specifically indicates the presence of two water molecules per quercetin molecule, which contributes to its stability and crystalline structure. This highly purified ingredient is typically obtained through meticulous extraction and purification processes, ensuring a high-purity product that meets stringent industry standards. Its distinct yellow crystalline appearance is indicative of its flavonoid nature. Traditional medicine systems have long utilized Sophora japonica for its purported health-promoting properties, laying a historical foundation for modern scientific investigation into its active constituents, particularly quercetin. The granular presentation ensures uniform dispersion and ease of integration into dry blends and capsule fills, a critical factor for consistent product quality.

The health benefits of quercetin dihydrate are primarily attributed to its potent antioxidant and anti-inflammatory properties, which have been extensively studied. Research indicates that quercetin can scavenge free radicals, thereby reducing oxidative stress, a key factor in cellular aging and various chronic conditions. Its anti-inflammatory action is mediated through the inhibition of several inflammatory enzymes and pathways, including cyclooxygenase (COX) and lipoxygenase (LOX), as well as the suppression of pro-inflammatory cytokines such as TNF-α and IL-6. A study published in the Journal of Nutrition (2016) highlighted quercetin's ability to modulate immune responses, supporting its role in immune system regulation. Furthermore, quercetin has demonstrated a capacity to support cardiovascular health by improving endothelial function, reducing blood pressure in hypertensive individuals, and inhibiting LDL oxidation, as evidenced by meta-analyses in journals like Circulation (2015). It also acts as a senolytic agent, selectively clearing senescent cells, which contributes to its potential anti-aging effects. These diverse mechanisms underscore quercetin's broad therapeutic potential across multiple physiological systems, making it a valuable ingredient for comprehensive wellness formulations.

Granular Quercetin Dihydrate from Sophora japonica is a versatile ingredient, widely applied in dietary supplements targeting immune support, cardiovascular health, and anti-aging formulations. Its stability and excellent flow properties make it ideal for encapsulation, tableting, and incorporation into powdered drink mixes. When sourcing, critical quality considerations include purity, particle size, and absence of contaminants, typically verified through rigorous analytical testing such as HPLC for quercetin content and heavy metal screening. Bioavailability is a key factor, and ongoing research explores strategies like micronization or phospholipid complexation to enhance absorption, although the dihydrate form itself offers advantages over anhydrous versions in certain contexts. Clinical trials have explored quercetin's efficacy in areas such as exercise performance, allergy relief, and metabolic syndrome. For instance, a randomized, double-blind, placebo-controlled trial published in Medicine & Science in Sports & Exercise (2010) found that quercetin supplementation improved endurance exercise capacity. Another meta-analysis in Phytotherapy Research (2019) consolidated evidence on quercetin's role in attenuating allergic responses. These scientific insights reinforce its standing as a research-backed ingredient for advanced nutritional products, emphasizing the importance of utilizing high-quality, standardized raw materials.